Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Katrin Andreasson
PROVIDER: E-GEOD-67306 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Brain : a journal of neurology 20160513 Pt 7
Identifying preventive targets for Alzheimer's disease is a central challenge of modern medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes COX-1 and COX-2, reduce the risk of developing Alzheimer's disease in normal ageing populations. This preventive effect coincides with an extended preclinical phase that spans years to decades before onset of cognitive decline. In the brain, COX-2 is induced in neurons in response to excitatory synaptic activity and in g ...[more]