Potential of Neuropeptide PACAP38 Therapy for Brain Ischemia: Insights from Bioinformatics Analysis of the High-throughput DNA Microarray Analyses Data in PMCAO Mouse Model using Ischemic Core and Penumbra Transcriptomic Data

ABSTRACT: Permanent middle cerebral artery occlusion (PMCAO) mouse model has been established and used by our group with a focus on systematically investigating effects of the neuropeptide pituitary adenylate-cyclase activating polypeptide (PACAP38) on the ischemic brain. Using an intracerebroventrically PACAP38 (1 pmol) injection over a control saline (0.9% sodium chloride, NaCl) treatment, we have been successful in generating a vast inventory of gene expression data in both whole hemispheres and specific brain regions of infract/ischemic core (IC) and penumbra (P) with high-throughput Agilent whole genome 4 × 44 K oligo DNA microarray chips. In this study, we first perform a specific analysis of the gene expression in the IC and P compared to the healthy control regions to know the gene profile s

ORGANISM(S): Mus musculus

SUBMITTER: RANDEEP RAKWAL 

PROVIDER: E-GEOD-67421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress