Expression data from OSKM-mediated 2nd reprogramming cells and the corresponding iPS cell line

ABSTRACT: Forced expression of four transcription factors Oct4,Sox2, Klf4 and Myc (OSKM) induces somatic cell reprogramming towards pluripotency. Major efforts have been made to characterize the molecular events involved in this process. Yet, it remains elusive how gene expression change, epigenetic landscape remodelling and cell fate conversion are triggered by expression of these Yamanaka factors.To address this gap,we utilized a secondary inducible reprogramming system and performed genome-wide profilings of Oct4 binding, histone modification(H3K4me3/H3K27me3/H3K4me1/H3K27ac), and gene expression analysis during this process. Through integrative analysis, we revealed stage-specific Oct4 binding and enhancer signatures in consistence with gene expression changes,in which the initial regression of

ORGANISM(S): Mus musculus

SUBMITTER: Min Li 

PROVIDER: E-GEOD-67462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress