Omic Personality: The Longitudinal Consistency of Transcriptional, Epigenetic and Clinical Profiles [RNA-Seq]

ABSTRACT: Background: Personalized medicine is predicated on the notion that individual biochemical and genomic profiles are relatively constant in times of good health and to some extent predictive of disease or therapeutic response. We report a pilot study quantifying gene expression and methylation profile consistency over time, addressing the reasons for individual uniqueness, and its relation to N=1 phenotypes. Methods: Whole blood samples from 4 African American women, 4 Caucasian women, and 4 Caucasian men drawn from the Atlanta Center for Health Discovery and Well Being study at three successive 6-month intervals were profiled by RNASeq, miRNASeq, and Illumina Methyl-450 arrays. Standard regression approaches were used to evaluate the proportion of variance for each type of omic measure

ORGANISM(S): Homo sapiens

SUBMITTER: Greg Gibson 

PROVIDER: E-GEOD-67488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress