ADAR1 regulates the resistance of melanoma cells to T cells via miR-222 and ICAM1

ABSTRACT: The blossom of immunotherapy in melanoma highlights the need to delineate mechanisms of immune resistance. Recently, we have demonstrated that the RNA editing protein, adenosine deaminase acting on RNA-1 (ADAR1) is down-regulated during metastatic transition of melanoma, which enhances melanoma cell proliferation and tumorigenicity. Here we investigate the role of ADAR1 in melanoma immune resistance. Importantly, knockdown of ADAR1 in human melanoma cells induces resistance to tumor infiltrating lymphocytes in a cell contact-dependent mechanism. We show that ADAR1, in an editing-independent manner, regulates the biogenesis of miR-222 at the transcription level and thereby Intercellular Adhesion Molecule 1 (ICAM1) expression, which consequently affects melanoma immune resistance. ADAR1 th

ORGANISM(S): Homo sapiens

SUBMITTER: jasmine jacob 

PROVIDER: E-GEOD-67496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress