Reverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Uma Shankavaram
PROVIDER: E-GEOD-67502 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Modulation of miR-21 signaling by MPS1 in human glioblastoma.
Maachani Uday B UB Tandle Anita A Shankavaram Uma U Kramp Tamalee T Camphausen Kevin K
Oncotarget 20160801 33
Monopolar spindle 1 (MPS1) is an essential spindle assembly checkpoint (SAC) kinase involved in determining spindle integrity. Beyond its mitotic functions, it has been implicated in several other signaling pathways. Our earlier studies have elaborated on role of MPS1 in glioblastoma (GBM) radiosensitization. In this study using reverse phase protein arrays (RPPAs), we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumo ...[more]
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