Transcription profiling of human peripheral blood monocytes in periodontal therapy

ABSTRACT: Periodontal infections have been associated with systemic inflammation and risk for atherosclerosis and vascular disease. We investigated the effects of comprehensive periodontal therapy on gene expression of peripheral blood monocytes. Approximately 1/3 of the patients showed substantial changes in expression in genes relevant to innate immunity, apoptosis, and cell signaling. We concluded that periodontal therapy may alter monocytic gene expression in a manner consistent with a systemic anti-inflammatory effect. Experiment Overall Design: Fifteen patients with periodontitis contributed with blood samples at four time points: 1 week prior to periodontal treatment (#1), at treatment initiation (baseline, #2), 6 weeks (#3) and 10 weeks post-baseline (#4). At baseline and 10 weeks, periodont

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Pavlidis 

PROVIDER: E-GEOD-6751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress