In vivo gene expression changes in EW5 Ewing sarcoma xenografts after IGF-1R or mTOR blockade

ABSTRACT: Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pathways that promote oncogenesis, cell growth, invasion, and metastasis. Among them, translocation-mediated up-regulation of the insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) are of particular importance since they work in concert to facilitate IGF-1R expression and ligand-induced activation, respectively, of proven importance in ES transformation. When used as a single agent in Ewing sarcoma therapy, IGF-1R or mTOR inhibition leads to rapid counter-regul

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Ludwig 

PROVIDER: E-GEOD-67529 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress