Expression of genes involved in the T cell pathway in circulating immune cells of cattle orally challenged with BASE

ABSTRACT: Bovine Amyloidotic Spongiform Encephalopathy (BASE) is a variant of classical BSE that affects cows and can be transmitted to primates and mice.The present work examined the effects of BASE on gene expression in circulating immune cells. Ontology analysis of genes differentially expressed between cattle orally challenged with brain homogenate from cattle confirmed as BASE and control cattle identified three main pathway which were affected. Within the immune function pathway, the most affected genes were related to the T Cell Receptor-mediated T Cell activation pathways. The differential expression of these genes in BASE challenged animals at 10,12 and 24 months following challenge vs controls, was investigated. The results of this study show that the effects of prion diseases are not limi

ORGANISM(S): Bos taurus

SUBMITTER: Andrea Trovato 

PROVIDER: E-GEOD-67576 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress