Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment

ABSTRACT: Background Identification of patients at risk of tuberculosis relapse following treatment would revolutionize clinical trials of new drugs and regimens and facilitate clinical management. The study aim was to determine whether tuberculosis patients who subsequently suffer relapse have different immune responses to mycobacteria in vitro compared to patients who remain cured for two years post-treatment. Methods First episode pulmonary tuberculosis patients were recruited into a surrogate marker study in Cape Town, South Africa. Peripheral blood samples were collected at diagnosis and after two and four weeks of tuberculosis treatment. Diluted blood was cultured with live Mycobacterium tuberculosis for six days and cellular RNA was frozen. Gene expression in samples from ten patients who sub

ORGANISM(S): Homo sapiens

SUBMITTER: Jackie Cliff 

PROVIDER: E-GEOD-67589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress