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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Whole genome expression microarray analysis in quadriceps of wild-type and NF90-NF45 double transgenic mouse

ABSTRACT: The complex of NF90 and NF45 is known to participate in transcriptional regulation, mRNA stabilization and microRNA biogenesis in vitro. However, the physiological function of the NF90-NF45 complex is still unclear. To elucidate its functions, we generated NF90-NF45 double transgenic (dbTg) mice. Robust expression of NF90 and NF45 was detected in skeletal muscle. As mentioned above, NF90-NF45 complex is involved in regulation of genes via transcription and RNA metabolism. To identify genes regulated by NF90-NF45, we performed comprehensive analyses of mRNA expression in quadriceps of wild-type (WT) and NF90-NF45 dbTg mice. mRNA expression profile in quadriceps comparing WT and NF90-NF45 dbTg mice.

ORGANISM(S): Mus musculus

SUBMITTER: Shuji Sakamoto

PROVIDER: E-GEOD-67591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA (miRNA) expression profile in quadriceps of wild-type (WT) and NF90-NF45 double transgenic (dbTg) mice.

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Whole genome expression microarray analysis in quadriceps of wild-type and NF90-NF45 double transgenic mouse

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MicroRNA (miRNA) expression profile in quadriceps of wild-type (WT) and NF90-NF45 double transgenic (dbTg) mice.

Project description:To investigate regulation of miRNA biogenesis by NF90-NF45 complex, we performed comprehensive analysis of miRNA expression in quandriceps of WT and NF90-NF45 dbTg mice.

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Whole genome expression microarray analysis in hepatocellular carcinoma cell line, Huh7 cells, treated with siRNA targeting for nuclear factor 90 (siNF90)

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Minimal expression of dysferlin prevents development of muscular dystrophy in dysferlin exon 40a knockout mice (second dataset)

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Minimal expression of dysferlin prevents development of muscular dystrophy in dysferlin exon 40a knockout mice

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Muscle Hypertrophy Induced by Myostatin Inhibition Accelerates Degeneration in Dysferlinopathy

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