Gene expression changes in Porphyromonas gingivalis W83 after inoculation in rat oral cavity

ABSTRACT: The aim of this study is to investigate the alterations in gene expression in Porphyromonas gingivalis W83 after inoculation in rat oral cavity. P.gingivalis W83 inoculation in rat oral cavity caused inflammatory responses in gingival tissues and destroyed host alveolar bone. Microarray analysis revealed that 42 genes were upregulated, and 22 genes were downregulated in the detected 1786 genes in the inoculated P.gingivalis W83. Products of these upregulated and downregulated genes are mainly related to transposon functions, cell transmembrane transportation, protein and nucleic acid metabolism, energy metabolism, cell division and bacterial pathogenicity.P.gingivalis W83 has a pathogenic effect on host oral cavity. Meanwhile, inflammatory oral environment alters P.gingivalis W83 gene expr

ORGANISM(S): Porphyromonas gingivalis W83

SUBMITTER: Jian Zhao 

PROVIDER: E-GEOD-67608 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress