Morphological and molecular descriptors of the developmental cycle of Babesia divergens parasites in human erythrocytes

ABSTRACT: Human babesiosis, especially caused by the cattle derived Babesia divergens parasite, is on the increase, resulting in renewed attentiveness to this potentially life threatening emerging zoonotic disease. The molecular mechanisms underlying the pathophysiology and intra-erythrocytic development of these parasites are poorly understood. This impedes concerted efforts aimed at the discovery of novel anti-babesiacidal agents. By applying sensitive cell biological and molecular functional genomics tools, we describe the intra-erythrocytic development cycle of B. divergens parasites from immature, mono-nucleated ring forms to bi-nucleated paired piriforms and ultimately multi-nucleated tetrads that characterizes zoonotic Babesia spp. This is further correlated for the first time to nuclear cont

ORGANISM(S): Babesia divergens

SUBMITTER: Ingrid Rossouw 

PROVIDER: E-GEOD-67677 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress