Methylome-wide analysis of chronic HIV infected patients and healthy controls

ABSTRACT: Current therapy has turned HIV infection into a chronic condition. Clinically, some patients suffer prematurely from ailments associated with advanced age; however, the relationship between HIV and aging is unclear. Here we have collected a large cohort of HAART treated HIV+ subjects with both recent and chronic infection and recapitulated the shared phenotype of HIV and age. To further understand this signal, we applied validated models of DNA methylation-based biological age to establish a clear link between HIV infection and molecular age advancement. We then show this result to be robust to HIV duration, cellular composition, and general methylome disorder. Finally we show a pattern of hypomethylation in HIV+ individuals at the HLA locus. Together these results lead to a much-needed be

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Gross 

PROVIDER: E-GEOD-67705 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress