Sex differences in the translatome of Drosophila fruitless-expressing neurons that underlie reproductive behaviors

ABSTRACT: Adult reproductive behaviors in Drosophila melanogaster males and females are vastly different. Yet, neurons that express sex-specifically spliced fruitless transcripts (fru P1) underlie these behaviors in both sexes. How the same set of neurons can drive such different behaviors is an important and unresolved question in developmental genetics. A particular challenge is that fru P1-expressing neurons are only 2-5% of the adult nervous system, making studies of adult head tissue, or even the whole brain, unlikely to yield informative inferences. Translating Ribosome Affinity Purification (TRAP) identifies the actively translated pool of mRNAs from fru P1-expressing neurons and allowed us to conduct a sensitive, cell-specific assay of gene expression. The male and female fru P1-expressin

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Michelle Arbeitman 

PROVIDER: E-GEOD-67743 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress