Aneuploid clones (Sunshine et al 2015)

ABSTRACT: Aneuploidy is a hallmark of tumor cells and yet the precise relationship between aneuploidy and a cell’s proliferative ability, or cellular fitness, has remained elusive. In this study we have combined a detailed analysis of aneuploid clones isolated from laboratory-evolved populations of Saccharomyces cerevisiae with a systematic, genome-wide screen for the fitness effects of telomeric amplifications to address the relationship between aneuploidy and cellular fitness. We found that aneuploid clones rise to high population frequencies in nutrient-limited evolution experiments and show increased fitness relative to wild-type. Direct competition experiments confirmed that three out of four aneuploid events isolated from evolved populations were themselves sufficient to improve fitness. T

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Maitreya Dunham 

PROVIDER: E-GEOD-67769 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress