Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance

ABSTRACT: Background: Psoriasis is a chronic disease characterized by the development of scaly red skin lesions and possible co-morbid conditions. The psoriasis lesional skin transcriptome has been extensively investigated, but mRNA levels do not necessarily reflect protein abundance. Methods: Lesional (PP) and uninvolved (PN) skin samples from 14 patients were analyzed using high-throughput complementary DNA sequencing (RNA-seq) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: We identified 4122 differentially expressed genes (DEGs) along with 748 differentially expressed proteins (DEPs). Global shifts in mRNA were modestly correlated with changes in protein abundance (r = 0.40). We identified similar numbers of increased and decreased DEGs, but 4-fold more increased than d

ORGANISM(S): Homo sapiens

SUBMITTER: William Swindell 

PROVIDER: E-GEOD-67785 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress