Expression data from liver, PFC and amygdala of mice treated with PPAR agonists

ABSTRACT: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists have demonstrated therapeutic properties for several brain disorders, including alcohol dependence. PPAR agonists decrease ethanol consumption and reduce withdrawal severity and susceptibility to stress-induced relapse in rodents. However, the cellular and molecular mechanisms facilitating these properties have yet to be investigated and little is known about their effects in the brain. We tested three PPAR agonists in a continuous access two-bottle choice (2BC) drinking paradigm and found that tesaglitazar and fenofibrate decreased ethanol consumption in male C57BL/6J mice while bezafi

ORGANISM(S): Mus musculus

SUBMITTER: Laura Ferguson 

PROVIDER: E-GEOD-67796 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress