Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Microarray data obtained from control, cbtRNAi and cbtOE flies

ABSTRACT: Microarray data obtained from control, cbtRNAi (cabut RNAi), and cbtOE (cabut overexpression) flies. From each strain, fly heads at two different time points during the day–night cycle (ZT3 and ZT153) were collected. Fly heads were collected and RNA was extracted. RNA was then used to prepare a probe that was hybridized to Drosophila 2.0 gene expression arrays (Affymetrix). Two samples of cbtRNAi, two samples of cbtOE and two samples of the control flies (cyo).

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sebastian Kadener 

PROVIDER: E-GEOD-67865 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing.

Bartok Osnat O   Teesalu Mari M   Ashwall-Fluss Reut R   Pandey Varun V   Hanan Mor M   Rovenko Bohdana M BM   Poukkula Minna M   Havula Essi E   Moussaieff Arieh A   Vodala Sadanand S   Nahmias Yaakov Y   Kadener Sebastian S   Hietakangas Ville V  

The EMBO journal 20150427 11

Nutrient sensing pathways adjust metabolism and physiological functions in response to food intake. For example, sugar feeding promotes lipogenesis by activating glycolytic and lipogenic genes through the Mondo/ChREBP-Mlx transcription factor complex. Concomitantly, other metabolic routes are inhibited, but the mechanisms of transcriptional repression upon sugar sensing have remained elusive. Here, we characterize cabut (cbt), a transcription factor responsible for the repressive branch of the s  ...[more]

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