Altered neurotrophin expression profiles in the nucleus of the solitary tract of spontaneously hypertensive rats

ABSTRACT: Our previous findings suggest that the nucleus of the solitary tract (NTS), a pivotal region for regulating the set-point of arterial pressure, exhibits abnormal inflammation in pre-hypertensive and spontaneously hypertensive rats (SHRs) together with elevated anti-apoptotic and low apoptotic factor levels compared with that of normotensive Wistar–Kyoto (WKY) rats. Whether this chronic condition affects neuronal growth and plasticity in the NTS remains unknown. To unveil the characteristics of the neurodevelopmental environment in the NTS of hypertensive rats, we investigated the gene expression profile of neurotrophins and their receptors in SHRs compared to that of normotensive rat WKY. The NTS was dissected from the brain of 6 SHRs and 6 WKY rats and the total RNA was extracted. In both

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sabine Gouraud 

PROVIDER: E-GEOD-67874 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress