Regulation of protein translation during mitosis

ABSTRACT: Entry into and exit from mitosis is driven by precisely-timed changes in protein abundance, and involves transcriptional regulation and protein degradation. However, the role of translational regulation in modulating cellular protein content during mitosis remains poorly understood. Here, using ribosome profiling, we show that translational, rather than transcriptional regulation is the dominant mechanism for modulating protein synthesis at mitotic entry. The vast majority of regulated mRNAs are translationally repressed, which contrasts previous findings of selective mRNA translational activation at mitotic entry. One of the most pronounced translationally repressed genes in mitosis is Emi1, an inhibitor of the anaphase promoting complex (APC), which is degraded during mitosis. We show th

ORGANISM(S): Homo sapiens

SUBMITTER: Marvin Tanenbaum 

PROVIDER: E-GEOD-67902 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress