RNA profiling by deepSAGE sequencing in the cortex of a migraine mouse model after induction of cortical spreading depression

ABSTRACT: Familial Hemiplegic Migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the a1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (“FHM1 R192Q mice”) exhibit an increased susceptibility to cortical spreading depression (CSD), the mechanism underlying migraine aura. Here we analysed gene expression profiles from isolated cortical tissue of FHM1 R192Q mice 24 hours after experimentally induced CSD in order to identify molecular pathways affected by CSD. Gene expression profiles were generated using deep Serial Analysis of Gene Expression sequencing. Our data reveal a signature of inflammatory signalling upon CSD in the cortex of both mutant and wild-

ORGANISM(S): Mus musculus

SUBMITTER: Else Eising 

PROVIDER: E-GEOD-67933 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress