BALF macrophage transcript analysis in response to butylated hydroyxtoluene treatment in mice deficient in TLR4

ABSTRACT: Background: Human lung adenocarcinoma (ADC), the predominant subtype of lung cancer, are at a disadvantage as the disease lacks available biomarkers and is not usually diagnosed until its later stages. We previously demonstrated that Tlr4-mutantmice were more susceptible to BHT-induced pulmonary inflammation (bronchoalveolar lavage macrophages and lymphocytes) and tumorigenesis in comparison to Tlr4-sufficient control mice. Differential transcriptional profiles were also noted in the whole lung tissue of the mice. The study objective was to elucidate the mechanisms underlying the protective effect of Tlr4 including differences in specific innate immune cell populations, their functional responses, and the influence of these cellular differences on the growth of ACD progenitor cell types.

ORGANISM(S): Mus musculus

SUBMITTER: Alison Bauer 

PROVIDER: E-GEOD-68067 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress