Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pigtail Macaques

ABSTRACT: Our earlier studies in pig-tailed macaques demonstrated varying SHIV susceptibility during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the luteal phase and predispose women to HIV-1 acquisition and transmission. In this study, we adopted a systems biology approach employing proteomics (tandem mass spectrometry), transcriptomics (RNA microarray hybridization), and other specific protein assays (enzyme-linked immunosorbent assays and multiplex chemokine-cytokine measurements) to characterize the effects of hormonal changes on the expression of innate factors and secreted proteins in the macaque vagina. Several antiviral factors and

ORGANISM(S): Macaca nemestrina

SUBMITTER: Gregory Tharp 

PROVIDER: E-GEOD-68079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress