Escherichia coli global gene expression due ciprofloxacin challenge in human whole blood

ABSTRACT: Treatment failures of antibiotic therapy are of major concern and can be caused by a misalignment of the antibiotic susceptibility determined in vitro with the behaviour of the pathogen in the patient. The aim of this study was to investigate the transcriptomic response of the uropathogenic strain E. coli CFT073 to antibiotic treatment in blood stream infection (BSI) models in order to understand and avoid antibiotic therapy failures in urosepsis treatments. Blood stream infection models were established by growing E. coli CFT073 in pooled human blood with and without ciprofloxacin. The antibiotic challenge was introduced at mid-logarithmic phase of growth of the organism to depict a clinical scenario. The responses were quantified by comparing to the responses at a given time point withou

ORGANISM(S): Escherichia coli CFT073

SUBMITTER: Senthil Gandi 

PROVIDER: E-GEOD-68106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress