Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Sampson 

PROVIDER: E-GEOD-68127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome Study Network (NEPTUNE), stratified by APOL1 risk genotype. Ninety subjects with proteinuria ≥0.5 g/d were enrolled at first biopsy for primary nephrotic syndrome and followed. Clinical outcomes were determined, and renal histomorphometry and se  ...[more]

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