An Immune and Inflammation Signature in Prostate Tumors of Smokers (part 1)

ABSTRACT: Current smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor induces metastasis. To identify smoking-induced alterations in human prostate tumors, we analyzed gene and protein expression of tumors from current, past, and never smokers and observed distinct molecular alterations in current smokers. Specifically, an immune and inflammation signature was identified in prostate tumors of current smokers that was either attenuated or absent in past and never smokers. Key characteristics of this signature included augmented immunoglobulin expression by tumor-infiltrating B cells, NF-kB activation, and increased interleukin-8 in tumor and blood. In an alternate approach to characterize smoking-induced oncogenic alterations, we explor

ORGANISM(S): Homo sapiens

SUBMITTER: Stefan Ambs 

PROVIDER: E-GEOD-68135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress