Cell type transcriptomics of hypothalamic energy-sensing neuron responses to fasting

ABSTRACT: AGRP neurons are a hypothalamic population that senses physiological energy deficit and consequently increases appetite. Molecular and cellular processes for energy-sensing and elevated neuronal output are critical for understanding the central nervous system response to energy deficit states, such as during weight-loss. Cell type-specific transcriptomics can be used to identify pathways that counteract weight-loss but, in adult mice, this has been limited by technical challenges. We report high-quality gene expression profiles of AGRP neurons under well-fed and energy deficit states. For comparison, we also analyzed POMC neurons, an intermingled population that suppresses appetite. This data newly identifies cell type-selective involvement of signaling pathways, ion channels, neuropeptide

ORGANISM(S): Mus musculus

SUBMITTER: Ken Sugino 

PROVIDER: E-GEOD-68177 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress