Comprehensive analysis of microRNA expression in the human developing brain reveals microRNA-10 as a caudalizing factor

ABSTRACT: MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor cells derived from human embryonic stem cells and human fetal brain. We found that several miRNAs displaying both age-specific and region-specific expression patterns. Among these miRNAs we identified miR-10 to be specifically expressed in the human hindbrain and spinal cord, while absent from rostral regions. Gain-of-function experiments further demonstrated that miR-10 alone could drive caudalization of human neural progenitors cells. Together, these data confirms a role for miRNAs in establi

ORGANISM(S): Homo sapiens

SUBMITTER: Malin Parmar 

PROVIDER: E-GEOD-68189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress