Sirt1 is essential for Aire-mediated induction of central immunological tolerance

ABSTRACT: Autoimmune regulator (Aire) is a unique transcriptional regulator that induces promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for induction of immunological self-tolerance. Although several recent studies provided very important molecular insights into how Aire operates, a more comprehensive understanding of this process still remains elusive. Here we demonstrate that a lysine deacetylase Sirtuin-1 (Sirt1) is predominantly expressed in mature Aire+ mTECs, where it is required for expression of Aire-dependent TRA genes and a subsequent induction of immunological self-tolerance. Our study elucidates a previously unknown molecular mechanism for Aire-mediated transcriptional regulation and uncovers a unique

ORGANISM(S): Mus musculus

SUBMITTER: Matthieu Giraud 

PROVIDER: E-GEOD-68190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress