MiR-1246 association with distant metastasis and poor prognosis in breast cancer patients

ABSTRACT: Circulating microRNAs have recently emerged as a new class of promising non-invasive cancer biomarkers. The purpose of this study was the identification by a high-throughput approach (miRNA microarray) of circulating miRNAs associated with breast cancer-derived distant metastasis. To achieve this goal, we resorted to archival plasma samples collected from patients in the control arm of a randomized clinical trial on stage I breast cancer. We compared plasma miRNA levels in patients that developed distant metastasis after a radical or conservative surgery and in those long-term disease-free. Microarray results were technically and independently validated by Real Time PCR. Subsequent in vitro, in vivo and in silico analyses were performed to investigate the miRNA biological/clinical signific

ORGANISM(S): Homo sapiens

SUBMITTER: Elena Landoni 

PROVIDER: E-GEOD-68373 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress