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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Systems analysis of uterine microenvironment in Treg depleted pregnant mice at 12 days after fertilization

ABSTRACT: Analysis of uterine microenvironment at gene expression level. The hypothesis tested in the present study was that Tregs orchestrated the immune reponse triggered in presence of embryo. Total RNA obtained from uterine microenvironment tissues of Treg depleted pregnant mice (12 days after fertilization) compared to control tissues (uterus from PBS treated pregnant mice).

ORGANISM(S): Mus musculus

SUBMITTER: Djamel NEHAR-BELAID

PROVIDER: E-GEOD-68432 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice.

Nehar-Belaid Djamel D Courau Tristan T Dérian Nicolas N Florez Laura L Ruocco Maria Grazia MG Klatzmann David D

Journal of immunology (Baltimore, Md. : 1950) 20151207 2

Embryos and tumors are both masses of dividing cells expressing foreign Ags, but they are not rejected by the immune system. We hypothesized that similar tolerogenic mechanisms prevent their rejection. Global comparison of fetal and tumor microenvironments through transcriptomics in mice revealed strikingly similar and dramatic decreases in expression of numerous immune-related pathways, including Ag presentation and T cell signaling. Unsupervised analyses highlighted the parallel kinetics and s ...[more]

PMID: 26643476

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Systems analysis of uterine microenvironment in Treg depleted pregnant mice at 12 days after fertilization

2015-12-10 | GSE68432 | GEO

Systems analysis of uterine microenvironment 4, 6, 8, 10, 11 or 12 days after fertilization

Project description:Analysis of uterine microenvironment at gene expression level. The hypothesis tested in the present study was that Tregs orchestrated the immune reponse triggered in presence of embryo Total RNA obtained from uterine microenvironment tissues (4, 6, 8, 10, 11 or 12 days after fertilization) compared to control tissues (uterus from non pregnant mice).

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Transcriptome profile form endometrial biopsy samples of pregnant and non-pregnant cows

Project description:Purpose: characterize the uterine transcriptome profiles of pregnant (P) versus non-pregnant (NP) cows during early pregnancy and attempted to define a potential set of marker genes that can be valuable for predicting pregnancy outcome. Methods: beef cows were synchronized and artificially inseminated at detected estrus. Six days after AI, jugular blood samples and a biopsy from the uterine horn contralateral to the ovary containing the corpus luteum were collected. Based on pregnancy outcome on day 30, samples were retrospectively allocated to the following groups: Pregnant and Non-Pregnant. Both groups had similar plasma progesterone concentrations on D6. Uterine biopsies were submitted to RNA-Seq analysis in a Illumina HiScanSQ platform. Results: The 272,685,768 million filtered reads were mapped to the Bos taurus reference genome and 14,654 genes were analyzed for differential expression between groups. Transcriptome data showed that 216 genes are differently expressed when comparing NP versus P uterine tissue (Padj≤0.1). More specifically, 36 genes were up-regulated in P cows and 180 are up-regulated in NP cows. Conclusions: this study characterized a unique set of genes, expressed in the uterus on 6 days after insemination, that indicate a receptive state leading to pregnancy success. Furthermore, expression of such genes can be used as potential markers to efficiently predict pregnancy success. endometrial mRNA profiles of pregnant and non-pregnant cows were generated by deep sequencing using Illumina HiScanSQ platform BioProject PRJNA268916 SRA Study SRP05036

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