Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

ABSTRACT: Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-life antibiotics is still uncharacterized. Using a mouse model mimicking pediatric antibiotic use, we found that therapeutic-dose pulsed antibiotic treatment (PAT) with a beta-lactam or macrolide altered both host and microbiota development. Early-life PAT accelerated total mass and bone growth, and resulted in progressive changes in gut microbiome diversity, population structure, and metagenomic content, with microbiome effects dependent on the number of courses and class of antibiotic. While c

ORGANISM(S): Mus musculus

SUBMITTER: Jiho Sohn 

PROVIDER: E-GEOD-68603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress