Gene expression Tet-mev-1 mouse fed either normal diet or high fat high sucrose diet compared with wild type mouse

ABSTRACT: To assess the effect of steatosis and oxidative stress on progression of liver fibrosis, we have employed whole genome microarray expression profiling as a discovery platform to identify genes that are related with oxidative stress- and steatosis-induced hepatic fibrogenesis. When wild type mice were fed high-fat/high-sucrose diet for 24 weeks, expression of 69 genes was changed more than 10-fold compared with wild type animals fed normal diet, 11 of which were categorized to lipid metabolic process. Moreover, expression of 208 genes showed more than 5-fold changes in Tet-mev-1 mice fed high-fat/high-sucrose diet compared with the same transgenic animals fed normal diet, and gene ontology analyses indicated significant changes in chemokine activity and chemokine receptor binding as well as

ORGANISM(S): Mus musculus

SUBMITTER: Yutaka Inagaki 

PROVIDER: E-GEOD-68632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress