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Genome-wide effects of the maternal embryonic leucine zipper kinase (MELK) in triple-negative breast cancer cells indicate context-dependent effects and p53 as a key determinant

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Cecilia Williams

PROVIDER: E-GEOD-68693 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.

Simon Marisa M Mesmar Fahmi F Helguero Luisa L Williams Cecilia C

PloS one 20170224 2

Triple-negative breast cancer (TNBC) is an aggressive, highly recurrent breast cancer subtype, affecting approximately one-fifth of all breast cancer patients. Subpopulations of treatment-resistant cancer stem cells within the tumors are considered to contribute to disease recurrence. A potential druggable target for such cells is the maternal embryonic leucine-zipper kinase (MELK). MELK expression is upregulated in mammary stem cells and in undifferentiated cancers, where it correlates with poo ...[more]

PMID: 28235006

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