Synergism of calcium sensing receptor and vitamin D receptor mediated signaling in epidermal differentiation [VDR KO]

ABSTRACT: Calcium and 1,25-dihydroxyvitamin D3 (1,25D3), through the actions of their respective receptors, the Ca2+-sensing receptor (CaSR) and the vitamin D receptor (VDR), potentiate keratinocyte differentiation. VDR regulates epidermal keratinocyte proliferation and differentiation by modulating gene transcription, whereas the CaSR, a member of the family C G-protein coupled receptor, calcium mobilizes intracellular calcium and induces the formation of cell-cell junctions. 1,25D3 augments the sensitivity of the prodifferentiating actions of calcium by increasing the expression of CaSR. CaSR- and VDR-deficient keratinocytes share common characteristics such as abnormal intercellular adhesion and sphigolipid metabolism. Both CaSR and VDR are abundantly expressed in epidermal stem cell populations

ORGANISM(S): Mus musculus

SUBMITTER: Yuko Oda 

PROVIDER: E-GEOD-68723 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress