Vitamin D receptor (VDR) regulates epidermal stem cells and cutanous wound healing [keratinocytes]

ABSTRACT: The vitamin D receptor (VDR) regulates cell proliferation and differentiation including epidermal keratinocytes by modulating transcription of its target genes. We are investigating the role of VDR in epidermal stem cells and their progenies in the regeneration process of epidermis and hair in the skin. VDR null mice are utilized in which VDR is specifically deleted in keratin 14 (K14) expressing keratinocytes by Cre-lox strategy. The impact of VDR deletion was evaluated by comparison of VDR null mice with no cre littermate control mice. The VDR was abundantly expressed in potential epidermal stem cells including basal cells in interfollicular epidermis (IFE), and in CD34 expressing bulge keratinocytes in hair follicles. Gene expression profiles and subsequent pathway analysis of stem cell

ORGANISM(S): Mus musculus

SUBMITTER: Yuko Oda 

PROVIDER: E-GEOD-68729 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress