Gene expression signatures that predict radiation exposure (mouse)

ABSTRACT: Gene expression analysis of peripheral blood leukocytes (PB MNCs) to develop expression profiles that accurately reflect prior radiation exposure. Keywords: Comparative, exposure dosage, C57BI6 Murine Irradiation Studies We have made use of gene expression analysis of peripheral blood mononuclear cells (PB MNCs) to develop expression profiles that accurately reflect prior radiation exposure. Importantly, we demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, ranging from 50 cGy to 1000 cGy. Likewise, a molecular signature of radiation response developed solely from irradiated human patient samples can predict and distinguish irradiated human PB samples from non-irradiated samples with a

ORGANISM(S): Mus musculus

SUBMITTER: Holly Dressman 

PROVIDER: E-GEOD-6873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress