Transcription profiling of rat mammary gland tissue from animals fed on a soy protein isolate, genistein or control casein diet

ABSTRACT: The role of diet in the prevention of breast cancer is widely accepted, yet little is known on how early dietary effects mitigate adult cancer risk. Soy consumption is associated with reduced breast cancer risk in women, an effect largely attributed to the soy isoflavone genistein (GEN). We previously showed lower chemically-induced mammary tumor incidence in young adult rats with lifetime dietary intake of soy protein isolate (SPI), a highly refined soy product in infant formula, than in those fed the control diet Casein (CAS). To gain insight into signaling pathways underlying dietary tumor protection, we performed genome-wide expression profiling of mammary epithelial cells from young adult rats lifetime fed CAS, SPI, or supplemental GEN-based diets. We identified mammary epithelial gen

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ying Su 

PROVIDER: E-GEOD-6879 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress