Long-range chromosome interactions mediated by cohesin shape circadian gene expression [4C]

ABSTRACT: Mammalian circadian rhythm is established by the negative feedback loops consisting of a set of clock genes, which lead to the circadian expression of thousands of downstream genes. As genome-wide transcription is organized under the high-order chromosome structure, it is unclear how circadian gene expression is influenced by chromosome structure. In this study, we focus on the function of chromatin structure proteins cohesin as well as CTCF (CCCTC-binding factor) in circadian rhythm. We analyzed the interactome of a Bmal1-bound enhancer upstream of a clock gene, Nr1d1, by 4C-seq and observed that cohesin binding sites are enriched in the interactome. Integrating circadian transcriptome data and cistrome data, we found that cohesin-CTCF co-binding sites tend to insulate the phases of circa

ORGANISM(S): Mus musculus

SUBMITTER: Yichi Xu 

PROVIDER: E-GEOD-68830 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress