Towards understanding the biological function of the unusual chaperonin GroEL1 of Mycobacterium tuberculosis

ABSTRACT: Expression data from wild type (H37Rv) and GroEL1(H37RvΔgroEL1::Hyg) mutant strains under a range of environmental stresses The 60 kDa heat shock proteins, also known as GroELs are components of the essential protein folding machinery of the cell, but are also dominant antigens in many infectious diseases. Although generally essential for cellular survival, in some organisms such as Mycobacterium tuberculosis, one or more paralogous GroELs are known to be dispensable. In M. tuberculosis, groEL2 is essential for cell survival, but the biological role of the non-essential GroEL1 is still elusive. To understand the relevance of GroEL1 in M. tuberculosis physiology, detailed transcriptomic analyses for the wild type H37Rv and groEL1 knockout (groEL1 KO) were performed under in vitro stress con

ORGANISM(S): Mycobacterium tuberculosis H37Rv

SUBMITTER: Tige Rustad 

PROVIDER: E-GEOD-68856 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress