Expression data from 5CC7 T cells stimulated in vivo
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rachel Gottschalk
PROVIDER: E-GEOD-68893 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.
Gottschalk Rachel A RA Hathorn Matthew M MM Beuneu Hélène H Corse Emily E Dustin Michael L ML Altan-Bonnet Grégoire G Allison James P JP
Proceedings of the National Academy of Sciences of the United States of America 20120105 3
The strength of T-cell receptor (TCR) stimulation and subsequent T-cell response depend on a combination of peptide-major histocompatibility complex (pMHC) density and potency. By comparing two different pMHC at doses yielding similar proliferation in vivo, we have highlighted unexpected differences in the qualitative and quantitative effects of TCR ligand. Measurements of cytokine sensitivity and two-photon imaging of T cell-dendritic cell (T-DC) interactions reveal discrimination between compa ...[more]
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