CaArray_golub-00095: Diffuse large B-cell lymphoma outcome prediction

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is curable in less than 50% of patients. Prognostic models based on pre-treatment characteristics, such as the International Prognostic Index (IPI), are currently used to predict outcome in DLBCL. However, clinical outcome models identify neither the molecular basis of clinical heterogeneity, nor specific therapeutic targets. We analyzed the expression of 6,817 genes in diagnostic tumor specimens from DLBCL patients who received cyclophosphamide, adriamycin, vincristine and prednisone (CHOP)-based chemotherapy, and applied a supervised learning prediction method to identify cured versus fatal or refractory disease. The algorithm classified two categories of patients with very different five-year overall s

ORGANISM(S): Homo sapiens

SUBMITTER: Mervi Heiskanen 

PROVIDER: E-GEOD-68895 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress