Normal colon top vs colon crypts
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Xin Chen
PROVIDER: E-GEOD-6894 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.
Kosinski Cynthia C Li Vivian S W VS Chan Annie S Y AS Zhang Ji J Ho Coral C Tsui Wai Yin WY Chan Tsun Leung TL Mifflin Randy C RC Powell Don W DW Yuen Siu Tsan ST Leung Suet Yi SY Chen Xin X
Proceedings of the National Academy of Sciences of the United States of America 20070919 39
Human colonic epithelial cell renewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways. To identify genetic programs of human colonic epithelial cell differentiation in vivo as well as candidate marker genes that define colonic epithelial stem/progenitor cells and the stem cell niche, we applied gene expression analysis of normal human colon tops and basal crypts by using expression microarrays with 30,000 genes. Nine hundred and sixty-nine cDNA clon ...[more]
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