H3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples

ABSTRACT: Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion in the number of CAG repeats in the coding region of exon 1 of the Huntingtin (HTT) gene. One of the most widely studied chromatin modifications is trimethylated lysine 4 of histone 3 (H3K4me3). Here, we conducted the first comprehensive study of H3K4me3 ChIP-sequencing in neuronal chromatin from the prefrontal cortex of six HD cases and six non-neurologic controls. We examined two classes of H3K4me3 peaks; those located near transcription start sites (TSSs) (termed “proximal”) and those located distantly from TSSs (termed “distal”). We detected 2,830 differentially enriched H3K4me3 peaks between HD and controls, with 55% of them down regulated in HD. We found an unexpected dis

ORGANISM(S): Homo sapiens

SUBMITTER: Zhiping Weng 

PROVIDER: E-GEOD-68952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress