CaArray_golub-00392: Gefitinib (Iressa) induces myeloid differentiation of acute myeloid leukemia

ABSTRACT: Cure rates for patients with acute myeloid leukemia (AML) remain low despite ever-increasing dose intensity of cytotoxic therapy. In an effort to identify novel approaches to AML therapy, we recently reported a new method of chemical screening based on the modulation of a gene expression signature of interest. We applied this approach to the discovery of AML-differentiation-promoting compounds. Among the compounds inducing neutrophilic differentiation was DAPH1 (4,5-dianilinophthalimide), previously reported to inhibit epidermal growth factor receptor (EGFR) kinase activity. Here we report that the Food and Drug Administration (FDA)-approved EGFR inhibitor gefitinib similarly promotes the differentiation of AML cell lines and primary patient-derived AML blasts in vitro. Gefitinib induced d

ORGANISM(S): Homo sapiens

SUBMITTER: Mervi Heiskanen 

PROVIDER: E-GEOD-68954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress