CaArray_golub-00460: Prediction of central nervous system embryonal tumour outcome based on gene expression

ABSTRACT: Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of childhood, but their pathogenesis is unknown, their relationship to other embryonal CNS tumours is debated, and patients' response to therapy is difficult to predict. We approached these problems by developing a classification system based on DNA microarray gene expression data derived from 99 patient samples. Here we demonstrate that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours (PNETs), atypical teratoid/rhabdoid tumours (AT/RTs

ORGANISM(S): Homo sapiens

SUBMITTER: Mervi Heiskanen 

PROVIDER: E-GEOD-68956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress