Histone methylation by the Kleefstra Syndrome protein EHMT1 mediates homeostatic synaptic scaling.

ABSTRACT: Homeostatic plasticity, a form of synaptic plasticity, maintains the fine balance between overall excitation and inhibition in developing and mature neuronal networks. Although the synaptic mechanisms of homeostatic plasticity are well characterized, the associated transcriptional program remains poorly understood. We show that the Kleefstra syndrome-associated protein, EHMT1, plays a critical and cell-autonomous role in synaptic scaling by responding to attenuated neuronal firing or sensory drive. Chronic activity deprivation increased the amount of neuronal dimethylated H3 at lysine 9 (H3K9me2), the catalytic product of EHMT1 and an epigenetic marker for gene repression. Genetic knockdown and pharmacological blockade of EHMT1 or EHMT2 prevented the increase of H3K9me2 and synaptic scalin

ORGANISM(S): Rattus norvegicus

SUBMITTER: giovanni iacono 

PROVIDER: E-GEOD-68960 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress