Transcription profiling of human HepG2 cells exposed to 2,3-Dimethoxy-1,4-naphthoquinone (DMNQ), N-nitrosodimethylamine (DMN), phenol and six heavy metals
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Koji Kawata
PROVIDER: E-GEOD-6907 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Classification of heavy-metal toxicity by human DNA microarray analysis.
Kawata Koji K Yokoo Hiroyuki H Shimazaki Ryuhei R Okabe Satoshi S
Environmental science & technology 20070501 10
Microarray technology is proving to be a useful tool to classify undefined environmental toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant-specific genetic markers by examining global effects of putative toxicants on gene expression profiles. The aim of this study was to evaluate the toxicities of six heavy metals through the comparison with gene expression patterns induced by well-known chemicals. For this purpose, we first identified the genes alte ...[more]
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