RTN1 IS A NOVEL MEDIATOR FOR PROGRESSION OF KIDNEY DISEASE

ABSTRACT: Gene expression profiling of kidneys from the murine model of HIV-associated nephropathy (HIVAN) identified an association between the expression of an endoplasmic reticulum (ER)-associated protein reticulon-1, RTN1, and the severity of kidney disease. Of the three known RTN1 isoforms, only RTN1A protein expression was increased in kidneys of murine models of HIVAN, diabetic nephropathy (DN), and renal fibrosis and humans with HIVAN and DN. Both mRNA and protein expression of RTN1-A in the kidneys correlated inversely with estimated glomerular filtration rate (eGFR) in patients with DN. In kidney cells, RTN1 overexpression induced ER stress/apoptosis, whereas RTN1 knockdown attenuated tunicamycin-, and hyperglycemia-induced ER stress/apoptosis. Incubation of kidney cells with high glucose

ORGANISM(S): Mus musculus

SUBMITTER: Chengguo Wei 

PROVIDER: E-GEOD-69074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress